publications & PREPRINTS
Bold indicates authors from the Liau Lab;
* indicates equally contributing authors; # indicates corresponding authors
28. Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
Xie, Xiaowen*; Zhang, Olivia*; Yeo, Megan J.R.*; Lee, Ceejay*; Tao, Ran; Harry, Stefan A.; Payne, Connor N.; Nam, Eunju; Paul, Leena; Li, Yiran; Kwok, Hui Si; Jiang, Hanjie; Mao, Hiabin; Hadley, Jennifer L.; Lin, Hong; Batts, Melissa; Gosavi, Pallavi M.; D’Angiolella, Vincenzo; Cole, Philip A.; Mazitschek, Ralph; Northcott, Paul A.; Zheng, Ning#; Liau, Brian B.# Nature 2025. [Publication | Preprint | Tweetorial | Nature News & Views]
27. UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors
Yeo, Megan J.R.*; Zhang, Olivia*; Xie, Xiaowen*; Nam, Eunju*; Payne, Connor N.; Gosavi, Pallavi M.; Kwok, Hui Si; Iram, Irtiza; Lee, Ceejay; Li, Jiaming; Chen, Nicholas; Nguyen, Khanh; Jiang, Hanjie; Wang, Zhipeng A.; Lee, Kwangwoon; Mao, Haibin; Harry, Stefan A.; Barakat, Idris A.; Takahashi, Mariko; Waterbury, Amanda L.; Barone, Marco; Mattevi, Andrea; Carr, Steven A.; Udeshi, Namrata D.; Bar-Peled, Liron; Mazitschek, Ralph; Cole, Philip A.; Liau, Brian B.#; Zheng, Ning#. Nature 2025. [Publication | Preprint | Tweetorial | Nature News & Views]
26. Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance
Waterbury, Amanda L.*; Caroli, Jonatan*; Zhang, Olivia.; Tuttle, Paloma; Liu, Chao; Li, Jiaming; Park, Ji Sung; Hoenig, Samuel M.; Barone, Marco; Furui, Airi, Mattevi, Andrea#; Liau, Brian B.# Nature Communications Accepted in Principle.
25. CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association
Yu, Ruofan; Roseman, Shelby A.; Siegenfeld, Allison P.; Gardner, Zachary; Nguyen, Son C.; Joyce, Eric F.; Jain, Rajan; Liau, Brian B.; Krantz, Ian D.; Alexander, Katherine#; Berger, Shelley L.# Nature Structural & Molecular Biology 2025. [Publication | Preprint]
24. Building the first base editors
Waterbury, Amanda L.; Iram, Irtiza; Liau, Brian B.# Nature Chemical Biology 2025, 21, 16-17. Invited perspective. [Publication]
23. Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase
Roh, Heejin*; Shen, Simon P.*; Hu, Yan*; Kwok, Hui Si; Siegenfeld, Allison P.; Lee, Ceejay.; Zepeda, Marc Anthony; Guo, Chun-Jie; Roseman, Shelby A.; Sankaran, Vijay G.; Buenrostro, Jason D.; Liau, Brian B.# bioRxiv 2024. [Preprint | Tweetorial]
22. Systematic Targeting of Protein Complexes with Molecular COUPLrs
Yang, Diane*; Harry, Stefan*; Chong, Harrison; Zhang, Edwin; Nordenfelt, Natalie; Chen, Nicholas; Lee, Christine; Kaluziak, Stefan; Codd, Elizabeth; Trivedi, Samay; Gohar, Magdy; McKnight, Giovan; Mitchell, Dawn; Ge, Maolin; Gao, Chengzhuo; Holmes, Zavontae; Yang, Wenxin; Smith, Abigail; Carlin, Alexander; Lazarov, Matthew; Khandelwal, Neha; Takahashi, Mariko; Zhang, Siwen; Leong, Heman; Luna, Hector M.; Chearavanont, Zander; Emonds, Kim; Popoola, George; Barakat, Idris; Onozato, Maristela; Mahamdeh, Mohammed S.S.; Fujino, Toshio; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Sun, Zhen-Yu; Heffron, Gregory; Hata, Aaron; Soberman, Roy; Liau, Brian B.; Iafrate, John A.#; Bar-Peled, Liron#. bioRxiv 2024. [Preprint]
21. An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing
Waterbury, Amanda L.*; Kwok, Hui Si*; Lee, Ceejay*; Narducci, Domenic N.; Freedy, Allyson M.; Su, Cindy; Raval, Shaunak; Reiter, Andrew H.; Hawkins, William; Lee, Kwangwoon; Li, Jiaming; Hoenig, Samuel M.; Vinyard, Michael E.; Cole, Philip A.; Hansen, Anders S.; Carr, Steven A.; Papanastasiou, Malvina; Liau, Brian B.# Molecular Cell 2024, 84, 2238–2254. [Publication | Tweetorial]
20. DNA methylation insulates exons from CTCF loops near nuclear speckles
Roseman, Shelby A.*; Siegenfeld, Allison P.*; Lee, Ceejay; Lue, Nicholas Z.; Liau, Brian B.# eLife 2024. [Reviewed Preprint | Preprint]
19. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
Lee, Kwangwoon; Barone, Marco; Waterbury, Amanda L.; Jiang, Hanjie; Nam, Eunju; DuBois-Coyne, Sarah E.; Whedon, Samuel D.; Wang, Zhipeng A.; Caroli, Jonatan; Neal, Katherine; Ibeabuchi, Brian; Dhoondia, Zuzer; Kuroda, Mitzi I.; Liau, Brian B.; Beck, Samuel#; Mattevi, Andrea#; Cole, Philip A.# Nature Chemical Biology 2024. [Publication]
18. DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
Takahashi, Mariko*; Chong, Harrison B*.; Zhang, Siwen*; Lazarov, Matthew J.; Harry, Stefan; Maynard, Michelle; White, Ryan; Murrey, Heather E.; Hilbert, Brendan; Neil, Jason R.; Gohar, Magdy; Ge, Maolin; Zhang, Junbing; Durr, Benedikt R.; Kryukov, Gregory; Tsou, Chih-Chiang; Brooijmans, Natasja; Alghali, Aliyu; Rubio, Karla; Vilanueva, Antonio; Harrison, Drew; Koglin, Ann-Sophie; Ojeda, Samuel; Karakyriakou, Barbara; Healy, Alexander; Assaad, Jonathan; Makram, Farah; Rachman, Inbal; Khandelwal, Neha; Tien, Pei-Chieh; Popoola, George; Chen, Nicholas; Vordermark, Kira; Richter, Marianne; Patel, Himani; Yang, Tzu-Yi; Griesshaber, Hanna; Hosp, Tobias; van den Ouweland, Sanne; Hara, Toshiro; Bussema, Lily; Dong, Rui; Shi, Lei; Rasmussen, Martin Q.; Domingues, Ana C.; Lawless, Aleigha; Fang, Jacy; Yoda, Satoshi; Nguyen, Linh P.; Reeves, Sarah M.; Wakefield, Farrah N.; Acker, Adam; Clark, Sarah E.; Dubash, Taronish; Fisher, David E.; Maheswaran, Shyamala; Haber, Daniel A.; Boland, Genevieve; Sade-Feldman, Moshe; Jenkins, Russel; Hata, Aaron; Bardeesy, Nabeel; Suva, Mario L.; Martin, Brent; Liau, Brian B.; Ott, Christopher; Rivera, Miguel N.; Lawrence, Michael S.#; Bar-Peled, Liron#. Cell 2024, 187, 2536–2556. [Publication]
17. Base editor scanning reveals activating mutations of DNMT3A
Garcia, Emma M.; Lue, Nicholas Z.; Liang, Jessica K.; Lieberman, Whitney K.; Hwang, Derek D.; Woods, James; Liau, Brian B.# ACS Chemical Biology 2023, 18, 2030–2038. [Publication | Preprint]
16. Base editor screens for in situ mutational scanning at scale
Lue, Nicholas Z.; Liau, Brian B.# Molecular Cell 2023, 83, 2167–2187. Review [Publication | Tweetorial]
Featured on the Cover of Molecular Cell
15. Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma
Kwok, Hui Si*; Freedy, Allyson M.*; Siegenfeld, Allison P.; Morriss, Julia W.; Waterbury, Amanda L.; Kissler, Stephen M.; Liau, Brian B.# Nature Chemical Biology 2023, 19, 1105–1115. [Publication | Preprint | Tweetorial | Nature Chemical Biology News & Views | Trends in Pharmacological Sciences Spotlight]
14. Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery
Ngan, Kevin C.; Hoenig, Samuel M.; Kwok, Hui Si; Lue, Nicholas Z.; Gosavi, Pallavi M.; Tanner, David A.; Garcia, Emma M.; Lee, Ceejay; Liau, Brian B.# eLife 2023, 12, e80640. [Publication | Preprint | Tweetorial]
13. Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
Zhang, Junbing**; Simpson, Claire M.; Berner, Jacqueline; Chong, Harrison B.; Fang, Jiafeng; Ordulu, Zehra; Weiss-Sadan, Tommy; Possemato, Anthony P.; Harry, Stefan; Takahashi, Mariko; Yang, Tzu-yi; Richter, Marianne; Patel, Himani; Smith, Abby E.; Carlin, Alexander D.; Hubertus de Groot, Adriaan F.; Wolf, Konstantin; Shi, Lei; Wei, Ting-Yu; Dürr, Benedikt R.; Chen, Nicholas J.; Vornbäumen, Tristan; Wichmann, Nina O.; Mahamdeh, Mohammed S.; Pooladanda, Venkatesh; Matoba, Yusuke; Kumar, Shaan; Kim, Eugene; Bouberhan, Sara; Oliva, Esther; Rueda, Bo R.; Soberman, Roy J.; Bardeesy, Nabeel; Liau, Brian B.; Lawrence, Michael; Stokes, Matt P.; Beausoleil, Sean A.; Bar-Peled, Liron#. Cell 2023, 186, 2361–2379. [Publication]
12. Chromatin complex dependencies reveal targeting opportunities in leukemia
Najm, Fadi J.; DeWeirdt, Peter; Moore, Molly M.; Bevill, Samantha M.; El Farran, Chadi A.; Macias, Kevin A.; Hegde, Mudra; Waterbury, Amanda L.; Liau, Brian B.; van Galen, Peter; Doench, John G.; Bernstein, Bradley E.# Nature Communications 2023, 14, 448. [Publication]
11. Base editor scanning charts the DNMT3A activity landscape
Lue, Nicholas Z.; Garcia, Emma M.; Ngan, Kevin C.; Lee, Ceejay; Doench, John G.; Liau, Brian B.# Nature Chemical Biology 2023, 19, 176–186. Published online 2022. [Publication | Preprint]
10. CRISPR-suppressor scanning for systematic discovery of drug-resistance mutations
Ngan, Kevin C.*; Lue, Nicholas Z.*; Lee, Ceejay; Liau, Brian B.# Current Protocols 2022, 2, e614. Protocol. [Publication]
9. Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery
Siegenfeld, Allison P.*; Roseman, Shelby A.*; Roh, Heejin; Lue, Nicholas Z.; Wagen, Corin C.; Zhou, Eric; Johnstone, Sarah E.; Aryee, Martin J.#; Liau, Brian B.# Nature Communications 2022, 13, 4199. [Publication | Preprint | Tweetorial]
8. Profiling the landscape of drug resistance mutations in neosubstrates to molecular glue degraders
Gosavi, Pallavi M.*; Ngan, Kevin C.*; Yeo, Megan J.R.; Su, Cindy; Li, Jiaming; Lue, Nicholas Z.; Hoenig, Samuel M.; Liau, Brian B.# ACS Central Science 2022, 8, 417–429. [Publication | Preprint | Tweetorial | ACS Central Science First Reactions]
7. Discovering new biology with drug-resistance alleles
Freedy, Allyson M.; Liau, Brian B.# Nature Chemical Biology 2021, 17, 1219–1229. Review. [Publication]
6. Discovery of C13-aminobenzoyl cycloheximide derivatives that potently inhibit translation elongation
Koga, Yumi*; Hoang, Eileen M.*; Park, Yongho; Keszei, Alexander F.A.; Murray, Jason; Shao, Sichen**; Liau, Brian B.# Journal of the American Chemical Society 2021, 143, 13473–13477. [Publication | Synfacts]
5. Gain-of-function genetic alterations of G9a drive oncogenesis
Kato, S., Weng, Q.Y., Insco, M.L., Chen, K.Y., Muralidhar, S., Pozniak, J., Diaz, J.M.S., Drier, Y., Nguyen, N., Lo, J.A., van Rooijen, E., Kemeny, L.V., Zhan, Y., Feng, Y., Silkworth, W., Powell, C.T., Liau, B.B., Xiong, Y., Jin, J., Newton-Bishop, J., Zon, L.I., Bernstein, B.E., Fisher, D.E. Cancer Discovery 2020, 10, 980–997. [Publication]
4. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
Vinyard, Michael E.*; Su, Cindy*; Siegenfeld, Allison P.*; Waterbury, Amanda L.*; Freedy, Allyson M.*; Gosavi, Pallavi M.*; Park, Yongho; Kwan, Eugene E.; Senzer, Benjamin D.; Doench, John G.; Bauer, Daniel E.; Pinello, Luca; Liau, Brian B.# Nature Chemical Biology 2019, 15, 529–539. [Publication]
3. A versatile synthetic route to cycloheximide and analogues that potently inhibit translation elongation
Park, Yongho; Koga, Yumi; Su, Cindy; Waterbury, Amanda L.; Johnny, Christopher L.; Liau, Brian B.# Angewandte Chemie International Edition 2019, 58, 5387–5391. [Publication]
2. Taking a STAP at core promoter–transcriptional cofactor specificity
Siegenfeld, Allison P.*; Lee, Ceejay*; Liau, Brian B.# Biochemistry 2019, 58, 3133-3135. Invited Commentary. [Publication]
1. Uncovering the cellular target of agelastatin A
Park, Yongho; Liau, Brian B.# Cell Chemical Biology 2017, 24, 542–543. Invited Commentary. [Publication]
prior to liau lab
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
Miller, T.E., Liau, B.B., Wallace, L.C., Morton, A.R., Xie, Q., Dixit, D., Factor, D.C., Kim, L.Y.J., Morrow, J.J., Wu, Q., Mack, S.C., Hubert, C.G., Gillespie, S.M., Flavahan, W.A., Hoffmann, T., Thummalapalli, R., Hemann, M.T., Paddison, P.J., Horbinski, C.M., Zuber, J., Scacheri, P.C., Bernstein, B.E., Tesar, P.J., Rich, J.N.# Nature 2017, 547, 355-359.
Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
Liau, B.B.*, Sievers, C.*, Donohue, L.K., Gillespie, S.M., Flavahan, W.A., Miller, T.E., Venteicher, A.S., Hebert, C.H., Carey, C.D., Rodig, S.J., Shareef, S.J., Najm, F.J., van Galen, P., Wakimoto, H., Cahill, D.P., Rich, J.N., Aster, J.C., Suvà, M.L., Patel, A.P.#, Bernstein, B.E.# Cell Stem Cell 2017, 20, 233–246.
RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation
Xie, Q., Wu, Q., Kim., L., Miller, T.E., Liau, B.B., Mack, S.C., Yang, K., Factor, D.C., Fang, X., Huang, Z., Zhou, W., Alazem, K., Wang, X., Bernstein, B.E., Bao, S., Rich, J.N#. Journal of Clinical Investigation 2016, 126, 2757–2772.
Insulator dysfunction and oncogene activation in IDH mutant gliomas
Flavahan, W.A.*, Drier, Y.*, Liau, B.B., Gillespie, S.M., Venteicher, A.S., Stemmer-Rachamimov, A.O., Suvà, M.L., Bernstein, B.E.# Nature 2016, 529, 110–114.
A multiplexed system for quantitative comparisons of chromatin landscapes
van Galen, P., Viny, A.D., Ram, O., Ryan, R.J.H., Cotton, M.J., Donohue, L., Sievers, C., Drier, Y., Liau, B.B., Gillespie, S.M., Carroll, K.M., Cross, M.B., Levine, R.L., Bernstein, B.E.# Molecular Cell 2016, 61, 170–180.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Pelish, H.E.*, Liau, B.B.*, Nitulescu, I.I., Tangpeerachaikul, A., Poss, Z.C., Da Silva, D.H., Caruso, B.T., Arefolov, A., Fadeyi, O., Christie, A.L., Du, K., Banka, D., Schneider, E.V., Jestel, A., Zou, G., Si, C., Ebmeier, C.C., Bronson, R.T., Krivtsov, A.V., Myers, A.G., Kohl, N.E., Kung, A.L., Armstrong, S.A., Lemieux, M.E., Taatjes, D.J., Shair, M.D.# Nature 2015, 526, 273–276.
A unified strategy for the synthesis of 7-membered-ring-containing Lycopodium alkaloids
Lee, A.S., Liau, B.B., Shair, M.D.# Journal of the American Chemical Society 2014, 136, 13442–13452.
Total syntheses of HMP-Y1, hibarimicinone, and HMP-P1
Liau, B.B., Milgram, B.C., Shair, M.D.# Journal of the American Chemical Society 2012, 134, 16765–16772.
Gram-scale synthesis of the A'B'-subunit of angelmicin B
Milgram, B.C., Liau, B.B., Shair, M.D.# Organic Letters 2011, 13, 6436–6439.
Total synthesis of (+)-fastigiatine
Liau, B.B., Shair, M.D.# Journal of the American Chemical Society 2010, 132, 9594–9595.
A study of the effect of Z- and E-olefinic geometry on the rates of ring closure of 13-membered dienes
Liau, B.B., Gnanadesikan, V., Corey, E.J.# Organic Letters 2008, 10, 1055–1057.